The Inquiry

Around 1 billion people around the world suffer from a mysterious neurological condition called migraine. Far more than just a headache, migraine is abnormal processing of the world around us that can have symptoms like loss of sight and speech, dizziness, nausea and extreme fatigue.There are drugs which can help those struggling with the condition like anti-depressants and anti-convulsants. However, they weren’t developed specifically for migraine and can come with quite a lot of side effects or simply not work.For a long time migraine medication has been a process of trial and error. But a new class of drugs called anti-CGRPs are being hailed as a breakthrough migraine medication. Anti-CGRPs have a small side effect profile and were designed specifically to target migraine. They work by blocking CGRP (Calcitonin Gene-Related Peptide) from building up in the body and triggering a receptor in the brain which turns on a head pain pathway causing the migraine attack.Earlier this year the National Institute of H

Bangladesh is set to hold parliamentary elections next January. But only time will tell whether there will be real change at the top or whether the current Prime Minister Sheikh Hasina and her Awami League will remain in power. In recent months there has been an increase in political protests calling for a neutral interim government ahead of the polls opening. But these protests have only resulted in increasing numbers of senior leaders of the opposition Bangladesh Nationalist Party being rounded up and put in jail. Historically, the country has had a fractured relationship with democracy since its birth in 1971, but the government for their part has denied accusations of democratic backsliding. So this week on the Inquiry we’re asking ‘Why is Bangladesh in turmoil?’ Contributors: Sabir Mustafa, a former Editor of the BBC Bengali Service, now based in Washington DC, USA Dr. Avinash Paliwal, Reader in International Relations, Department of Politics and International Relations, SOAS University of London

The head of Ukraine’s armed forces General Zaluzhny has a this frank take on his country’s conflict with Russia "Just like in the First World War, we have reached the level of technology that puts us into a stalemate." He explains that using drones and remote surveillance equipment in battlezones means each side knows what the other is doing. That slows down troops advancing ….and creates a standoff. In a separate essay offering solutions the general states that fresh tech innovation is the key to cracking it. President Zelensky disagreed, his office accuses the general of making “the aggressor’s job easier.” The Kremlin also denies there’s a deadlock. But with the world’s attention also focussed on the Middle East, has attention drifted away from the Ukraine conflict – and if it has what does that mean for Ukraine’s campaign? Charmaine Cozier asks if the war in Ukraine has reached a stalemate. She explores the current state of fighting which continues on the eastern frontline, and whether Ukraine

When the Referendum to give Australia’s Aboriginal and Torres Strait Islanders greater political rights was first announced, it was well received, with the early polls suggesting that more than sixty percent of Australians supported it. This was an opportunity for the establishment of an advisory body to Parliament that would allow Indigenous Peoples a voice on the issues affecting their own communities and for them to be recognised in the Australian constitution. The ‘YES’ campaign said their proposals outlined in the Uluru Statement from the Heart, requested a modest yet profound change, allowing Indigenous Australians to take their ‘rightful place’ in their own country. Whilst the ‘NO’ campaigners argued that the ‘Voice to Parliament’ would be racially divisive, giving Indigenous Peoples greater rights over other Australians. In the end Australia voted ‘NO’ to changing the status quo, by an overwhelming majority. This week on The Inquiry, we’re asking ‘What went wrong with Australia’s Indigenous call

The Human Cell Atlas is a project that has 3000 researchers in over 94 countries working to collect samples of every single cell in the human body. The idea is that an interactive map of the body will be created. It will be a reference for what every kind of normal human cell should look like. But that will also vary depending on who you are and where you live. It will give doctors a tool to measure illness and disease and make diagnosis and treatment much quicker. The database will enable any doctor, anywhere in the world, with the right kind of interface, to access the information. It could be ground-breaking for the treatment of disease and the democratisation of healthcare. Contributors: Dr Aviv Regev, one of the co-chairs of the Human Cell Atlas Dr Sarah Teichmann from the Wellcome Sanger Institute and the University of Cambridge Dr Piero Carninci, Geneticist, Transcriptome Technology and RIKEN Centre Sean Bendall, Associate Professor of pathology and immunology at Stanford University Presented b

After violence erupted between Hamas and Israel, President Biden flew to Tel Aviv to offer his ‘staunch’ ally US support. In a very public embrace of Israel, he reinforced a relationship that goes back decades to Israel's foundation. But does the US have the diplomatic influence to bring peace to the region? This week on the Inquiry: what can US diplomacy achieve in the Middle East. Contributors: David Sanger, White House and national security correspondent and senior writer for The New York Times Steven Cook, senior fellow for Middle Eastern Studies at the Council on Foreign Relations Emma Ashford, senior fellow at the Stimson Center Brian Katulis, vice president of policy at the Middle East Institute Presented by Gary O’Donoghue Produced by Louise Clarke Researched by Matt Toulson Co-ordinated by Jordan King Image: (Photo by GPO/ Handout/Anadolu via Getty Images)

Climate change and the war in Ukraine is transforming the geopolitics of the Arctic. Melting ice opens up the possibility of new trade routes making the region more valuable. Tensions in the area are rising as Russia turns to China for cooperation. China in return wants to position itself as a major power in the region. Geopolitical tensions mean that any disputes become harder to resolve and potentially more dangerous. And in a region that’s vulnerable to climate change science is also suffering – without cooperation between countries valuable data is being lost. Contributors: Andreas Østhagen, Senior Researcher at Fridtjof Nansens Institute Stefan Hedlund, Professor of Russian and East European Studies at Uppsala University in Sweden Matthew Funaiole, senior fellow of the China Power Project at the Center for Strategic and International Studies Sophie Arts, from the Geostrategy North team at the German Marshall Fund of the United States Presented by Emily Wither Produced by Louise Clarke an

Europe’s migration crisis began back in 2015, with the arrival of over a million refugees, the majority from the war in Syria. Many thousands more from different countries have since sought refuge on European shores for one reason or another, whilst the tightening of external borders and asylum laws have proved ineffective in stopping the boats. There have been years of disagreements over migration amongst the member states of the European Union, which have caused damage to the bloc’s unity. In recent months, however, it looked like some progress had been made towards a fairer and more uniform migration system, but a proposal to relocate people to different parts of Europe was met with opposition. As the flow of people into frontline countries like Italy, Greece and Spain looks set to continue in the future, it appears that collective action from the member states, looks further away. This week on The Inquiry we’re asking ‘Can Europe solve its migrant crisis?’ Contributors: Hanne Beirens, Director, Mig

The German government was elected with a plan to build 400,000 new homes a year – but it fell short last year by over 100,000. The country’s house building industry is in crisis, with hundreds of companies going into liquidation this year as order books are emptying and demand for new homes has fallen. So why can’t Germany build enough homes? A combination of high construction costs caused by inflation since the Covid pandemic, and increases in interest rates in recent years has produced a difficult business environment for a construction sector that is a significant part of the German economy. Along with falling demand, industry experts fear that regulations and bureaucracy are a factor in causing the crisis. Charmaine Cozier hears from: Dirk Salewski President of the German Housebuilding Federation who attended a recent summit hosted by Chancellor Olaf Scholz when the government announced a 14 point plan to revive housing construction. Alice Pitinni is the research director at Housing Europe, the Euro

At the recent BRICS economic summit in South Africa, India’s Prime Minister Narendra Modi and China’s President Xi Jinping had a rare face to face meeting. For years these two world powers have been in dispute over their ill-defined border in the Himalayan region. A military escalation of this dispute in 1962 led to the creation of the ‘line of actual control’ or the LAC, the de facto border between the two countries. Down the years there have been a number of clashes along the LAC and its commonly agreed that relations now are at their lowest point since 1962. And whilst India has taken steps to reduce its economic dependence on China in a bid to engage in trade relations on an equal footing, they are both competing to become the dominant power in the global south with financial aid and infrastructure projects. Both sides agreed at their BRICS meeting to intensify efforts to de-escalate border tensions. So this week on The Inquiry we’re asking ‘Can China and India fix their relationship?’ Contrib

The life expectancy of Americans has fallen in recent years after a long period when it had been increasing. There are a number of factors which contribute to the fall. The Covid pandemic, with over 1m deaths, made a significant impact on lowering the average life expectancy. In comparison with other peer countries, the USA also did not return to pre-Covid levels at the same rate. However there are also other important factors driving this, namely gun deaths and drug deaths as a result of opioid overdoses. And another major contributor to lower life expectancy in the States is inequality in the US healthcare system. In this edition of The Inquiry Tanya Beckett explores why US life expectancy is falling. She hears from Jeremy Ney an adjunct professor at Presidio Graduate School in San Francisco and author of American Inequality, a data project that highlights US inequality and regional divides. Dr. Mark Rosenberg helped set up the Centre for Disease Control’s National Centre for Injury Prevention an

The Palestinian President Mahmoud Abbas is ageing and his ruling Fatah party is deeply unpopular. There have been protests against him and the Palestinian Authority. Many Palestinians feel the PA has lost legitimacy. There’s no plan for how to choose a successor to Mahmoud Abbas and any candidate is likely to be controversial. There’s a risk that an unpopular replacement may throw the occupied territories into chaos, even violence, and have major implications for the future goals of Palestinian people. Contributors: Dalia Hatuqa, independent Palestinian journalist. Khalil Shikaki, Professor of Political Science and director of the Palestinian Center for Policy and Survey Research. Ahmad Khalidi, political analyst and writer on Palestinian and Middle East political and strategic affairs. Ines Abdel Razak, executive director of the Palestine Institute for Public Diplomacy. Presenter: Emily Wither Producer: Louise Clarke Researcher: Matt Toulson Editor: Tara McDermott Sound engineer: Jack Wood (Photo:

How much do you think about your gut? Are you taking a probiotic or prebiotic? If so, you’re not alone as globally we spend billions of dollars on soothing our stomachs. Our guts do so much more than just digest our food and there’s a very special connection to our brain. So how exactly does our gut work? And what do we need to do in order to keep it healthy? Presenter: Tanya Beckett Producer: Louise Clarke Researcher: Matt Toulson Sound engineer: Nicky Edwards Contributors: Geoff Preidis, a gastroenterologist at Baylor college of medicine at Texas children’s hospital in Houston (Photo: Man bites in to cheeseburger. Credit: Emanuele Cremaschi/Getty Images)

In July 2023 a group of lawmakers in the US held a session to explore evidence of extra-terrestrial life. The evidence included the famous Tic Tac videos of mysterious objects flying through the sky. Pilots described encounters with Unidentified Anomalous Phenomenon – or UAPs. Congress also heard of a secret US government programme that retrieves and reverse engineers materials made by non-humans, including crashed and intact craft – and possibly the remains of the entities that piloted them. So does this mean we are not alone in the universe? Do sightings and hearsay provide enough scientific data to answer a question that has been asked by humans for thousands of years – are we alone in the universe? Contributors: Greg Eghigian is professor of history and bioethics at Penn State University in the US. Leslie Kean is an investigative reporter. Adam Frank is Professor of Astrophysics at the University of Rochester, and author of The Little Book of Aliens. Dr Chelsea Haramia is a member of the UK SETI R

Working from home became the norm for millions of us around the globe during the Covid-19 pandemic, but now three years on some major employers are insisting on their employees returning to the office, for at least some part of the working week. The levels of working from home currently vary, depending on the country and its culture. The Netherlands are looking at legislation to allow employees the ability to work remotely, whilst in Japanese culture the preference for employees tends to be going into the office. So how do we navigate a future where both business and personnel needs are met to provide a good work life balance. This week on the Inquiry we’re asking ‘Is work from home working?’ Contributors: Jose Maria Barrero, Assistant Professor of Finance at ITAM Business School, Mexico and Co-Founder of WFH Research project Dr Saori Sugeno, Lecturer in Corporate Governance and International Business, Surrey Business School, University of Surrey Román Gil, Partner in law firm Sagardoy Abogadas, th

About 60 percent of the Amazon rainforest is in Brazil and it is home to more than 300 indigenous groups. But for centuries both the rainforest and its indigenous inhabitants have been under threat, from deforestation, agri-business, mining and politics. Brazil’s current president, Luis Ignácio de Silva, has made the future security of the Amazon and its peoples a key policy pledge. So far, the president has appointed a new minister for indigenous peoples and according to government figures, the first six months of this year saw a 33 percent drop in deforestation. But at the recent Amazon Summit in Belém, the president failed to commit to zero-deforestation, to the disappointment of indigenous leaders. They are calling for more protection for their land and their way of life, which they say is crucial to the future preservation of the Amazon and a matter for the whole world. This week on The Inquiry we are asking ‘Can Brazil’s indigenous population save the Amazon?’ Contributors: Pedro Cesarino, Pro

Environmental activists in the UK have disrupted high profile sporting events in an effort to persuade the government to stop oil development. How would stopping oil production impact those countries around the world with economies dependent on oil? Tanya Beckett explores the history of oil, the implications of the Ukraine war for its price, how countries like Nigeria and Norway are dependent on oil revenues, and the challenges facing new oil producers in the global south as they face international efforts to limit new oil development in order to meet international climate targets. Presenter Tanya Beckett Producer Phil Reevell Researcher Matt Toulson Editor Tara McDermott Technical producer Gareth Jones (Industrial offshore oil rig platform on the North Seacoast, UK. Credit Getty images)

South Africa once had the most abundant and cheap electricity on the continent. Now, it is experiencing power blackouts. It’s called loadshedding, the process by which the power company Eskom occasionally reduces the demand for electricity on the national grid. For many South Africans this means no electricity for up to ten hours a day, almost every day. The result is disruption to everyday life, impacting on work, education, sanitation, food and heating. In 1994 Nelson Mandela’s African National Congress party promised a better life for all South Africans. So why is South Africa’s infrastructure crumbling? Contributors: Duma Qgubule, economist and journalist Thomas Mnguni, campaigner with Groundwork Anton Eberhard, professor at the Power Futures Lab at the University of Cape Town Lungile Mashele, energy economist Presented by Audrey Brown Produced by Louise Clarke Researched by Anoushka Mutanda-Dougherty Edited by Tara McDermott and Tom Bigwood Technical producer Kelly Young Production co-ordina

In June 2023 the British government announced a £40 million pound pilot scheme to increase access to specialist weight management services in England -It reads “Using the latest drugs to support people to lose weight will be a game-changer.” The scheme will use prescription drugs like Wegovy and Ozempic, a once weekly injection that slows down the emptying of the stomach and suppresses the hunger hormone in our brains. Both these medications are made of the same of the same drug called Semaglutide. Semaglutide mimics the hormone released by the body when we eat food, helping people feel fuller for longer and suppressing mental chatter about various food cravings. When prescribed alongside diet, physical exercise and behavioural support, the drug can help obese people lose 15% of their body weight. Ozempic has been used to treat sufferers of type 2 diabetes since 2018 when doctors noticed that alongside increasing insulin the drug helped people lose weight. In 2021 the drug was approved as a fat loss injec

Venezuela is the country with the largest oil deposits, yet 3 in every 4 Venezuelan lives in extreme poverty. More than 7 million people are recorded as having left the country since 2015 in search of a better life, causing the largest ever displacement of people in Latin American history. And it’s only surpassed in numbers by those people leaving Ukraine. But Venezuela is not at war, its current humanitarian crisis is the result of years of political and economic turbulence. International sanctions, imposed on the country with the aim of pressing the government to change its policies and restore democracy have had little impact, other than making it more difficult for Venezuela’s economy to function. Presidential elections are due to be held in the country next year, but talks between the government and the opposition to ensure that they are free and fair are currently at a standstill. This week on The Inquiry we’re asking ‘Is Venezuela a failed state?’ Contributors: Maria Gabriela Trompetero