Dr. Howard Smith Oncall

Azathioprine Use Associated with Skin Cancer

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Synopsis

Azathioprine can curb IBD and arthritis but the latest study implicates it as a possible cause of skin cancer. Vidcast: https://youtu.be/x1VLkU920Kc _______ Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh. The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-06027-1