Collège De France (général)

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2023-2024Exploring the World of Protein Post-translational ModificationsConférence - Tony Hunter : Post-translational Modifications of Proteins – Why Nature Chose Phosphate to Modify ProteinsTony HunterSalk Institute, La Jolla, California, USARésuméThis lecture will provide an introduction to the world of post-translational modifications (PTMs) of proteins. Chemical modifications of protein surfaces serves as a mechanism to increase proteome diversity. More than 400 different PTMs are known, and PTM linkages can be either reversible or irreversible in nature. PTMs serve many functions, but reversible PTMs play particularly important roles in signal transduction, protein-protein interactions, subcellular localization of proteins and protein degradation. All reversible PTMs, such as phosphorylation, utilize a writer enzyme that adds the PTM and an eraser enzyme that removes the PTM, and in many cases the modified protein is recognized by a