Bulletproof Radio

Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you’ll learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports long-term longevity. This conversation reframes biohacking, anti-aging, and health from weight loss to muscle span, the length of time you live with strong, functional skeletal muscle. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Gabrielle Lyon, an accomplished physician and New York Times bestselling author of Forever Strong: A New, Science-Based Strategy for Aging Well, and author of the upcoming The Forever Strong Playbook, releasing January 27, 2026. Dr. Lyon pioneered the Muscl

Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.In this video, I explain how appetite is actually regulated, why synthetic shortcuts often create new problems over time, and what has quietly shut down the body’s natural satiety signals for so many people.Once you understand the pathway drugs are trying to imitate, the question stops being “how do I eat less?” and becomes “why was my body blocked from doing this in the first place?”This is about restoring a system, not overpowering it.Chapters0:00 - Introduction: Your Body’s Natural Ozempic0:53 - Hunger Is a Hormone Problem5:08 - How to Fix Your Hormone Signals7:28 - Why Ozempic Often Backfires10:54 - The Resistant Starch Solution15:03 - How to Use Resistant Starch18:12 - Rebuilding Your Gut Environment19:31 - Lifestyle Support for Gut HealthResources:  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track&nbs

This episode covers: • Real Food Reset in U.S. Dietary Policy The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ultra processed foods, added sugar, and sugary drinks. Dave breaks down why this matters beyond personal dieting: these guidelines influence school meals, SNAP and WIC, federal feeding programs, and they shape what eventually shows up on labels and in public institutions. He also shares how biohackers can use this shift as leverage to push for better food environments in schools, workplaces, and hospitals. -Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/07/kennedy-rollins-unveil-historic-reset-us-nutrition-policy-put-real-food-back-center-health • Drug Combo Extends Lifespan of Frail Old Mice by 73% A new aging study found that combining oxytocin with a compound called A5i extended the remaining lifespan of frail elderly male mice by 73%, while

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer’s Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift t

Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Theodore Achacoso and Boomer Anderson, leaders in Health Optimization Medicine and Practice. Dr. Achacoso is a physician-scientist and the founding pioneer of Health Optimization Medicine, known for his work on cellular networks, metabolomics, and mitochondrial function. Boomer Anderson is the CEO of Smarter Not Harder and Troscriptions, where he focuses on translating complex biology into practical tools for human performance and longevity.&

One freezing sip on a Tibetan mountain rewired his hunger, silenced cravings, and unlocked a kind of fat-burning “switch” no doctor ever mentioned. What happened next—Silicon Valley obsession, a global butter shortage, and a new theory of weight loss—might change how you see food forever.The only coffee I drink: Danger Coffee: https://dangercoffee.com/DAVE15Thank you to our sponsors!  - GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Resources:   • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • M

This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you’ll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Renteln, Co Founder and CEO of LUCY Nicotine, a company pioneering science led alternatives for adult nicotine users who want better options. Before launching LUCY, David was also a co founder of Soylent, where he helped pioneer new approaches to functional nutrition and metabolism. Together, Dave and David break down how nicotine works in the brain through acetylcholine and dopamine, why speed of absorption

Most people are struggling in modern relationships, and it is not because they are broken. It is because the systems around them are. In this episode, you’ll learn why roughly 65 percent of people operate from insecure attachment, why that quietly destroys energy, trust, and intimacy, and how secure attachment becomes a critical biohacking upgrade for human performance, longevity, and emotional resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Adam Lane Smith, MA Psych, a leading global expert on Attachment Theory and the neurobiology of human bonding. Adam has spent over 16 years studying and working in psychology, helping individuals, couples, and families repair broken relationships, rebuild trust, and develop secure attachment. His work focuses on skill-based nervous system training rather than talk therapy alone, often creating change in months instead of years. He now runs a g

Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode, you’ll get the 12 greatest mood boosters on Earth, not as a clickbait supplement list, but as the real biological levers that control dopamine sensitivity, hormones, neuroplasticity, and energy production.Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down in Dubai with friend of the show, Lucas Aoun, founder of Ergogenic Health and INB4, for a deep, experience driven conversation on dopamine, mood, and performance. Lucas is Australia’s leading biohacker, now based in Dubai, with a background in exercise science, naturopathy, and pharmacology. He is globally recognized for his work in dopamine regulation, testosterone optimization, and neurohormonal performance, and for rigorously testing protocols before recommending them.  Together, Dave and Lucas explore how dopamine receptor upregul

Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don’t reach the deep repair zone your body is built for. Thank you to our sponsors! -HeartMath | Go to https://www.heartmath.com/dave to save 15% off.-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.Chapters0:00 - Why 16-hour fasts don’t reach real fat burning0:54 - The myth of aging and what doctors overlook1:48 - How modern life damages your mitochondria2:48 - How fasting restores your body’s repair mode3:39 - Understanding the phases of fasting4:58 - Why short fasts cut results short5:34 - Day 1 of fasting6:45 - Day 2 of fasting7:22 - Day 3 of fasting8:24 - Common fasting mistakes that harm your body9:35 - How to prepare before your fast10:31 - The right way to refeed afterward

Back in 2024 with Calley Means at South by Southwest, we sat down and talked about his mission to flip the old American food pyramid upside down for the greater good. Well guess what, the pressure is finally working! This rerun is the ultimate receipt that focus, repetition, and smart lobbying for human health can still move the needle! Host Dave Asprey sits down with Calley Means, entrepreneur, policy advocate, and co-author of Good Energy. Together, they break down how the U.S. healthcare system became a sick-care system, why ultra-processed food dominates public policy, and how individuals can reclaim autonomy over their biology. From CGMs and metabolic health to food subsidies, lobbying, and free speech, this episode challenges deeply held assumptions about medicine, nutrition, and personal responsibility.You’ll Learn: • Why chronic disease is the most profitable business model in modern history • How metabolic dysfunction drives obesity, diabete

Creatine is a hot subject right now, but I’m guessing you might not know as much about it as you could. Well step into a new creatine masterclass with our friends from Qualia. This episode shows you why it is not just for muscle, but one of the most powerful and well studied upgrades for brain energy, metabolism, sleep resilience, and long term human performance. You will learn how creatine supports mitochondria, buffers ATP, reduces cravings, and helps you think, train, and recover with more energy instead of relying on willpower. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Greg Kelly for a deep, practical masterclass on creatine and energy biology. Greg Kelly is a naturopathic physician, functional medicine expert, and longtime researcher in supplements and nootropics. He has spent decades studying creatine, mitochondrial function, cognition, and perf

You’re about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other and the science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, and anti aging without all the tribal thinking that can plague modern health conversations!  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dan Buettner for a rare co hosted podcast that explores where biohacking and Blue Zones philosophy clash and where they surprisingly align. Dan Buettner is a National Geographic Explorer, Emmy Award winning producer, and five time New York Times bestselling author. He is best known for identifying the Blue Zones, regions of the world where people live th

Most men think ED is just a performance issue. It’s not. It’s one of the earliest warning signs of cardiovascular decline and it often appears years before chest pain, shortness of breath, or heart attack symptoms.Thank you to our sponsors! -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.-GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.Chapters00:00 - The “Legal Blue Pill” Myth & Hidden Danger00:57 - What ED Actually Is (Not the Commercial Version)01:45 - Circulation, Arteries & the Real Root Cause03:27 - The Problem with Relying on ED Pills05:03 - Treat ED as a Cardiovascular Symptom05:55 - Patterns That Reveal Vascular Decline07:10 - The ED–Heart Attack Countdown Window08:14 - How To Fix This Problem10:10 - Microdosing Cialis for Vascular Support10:45 - Aspirin as Another Option11:15 - Lifestyle Drivers of Vascular Damage & Solutions13:15 - Movement, Walking & Circulation Basics13:40 - The Mitochon

This episode covers: • Colon Cancer in the Young and Why Risk May Start in Infancy New reporting highlights a troubling rise in early-onset colon cancer, including cases in highly fit endurance athletes. Researchers identified a distinct DNA damage signature linked to colibactin, a toxin produced by certain strains of E. coli, with evidence suggesting the damage may occur in infancy. Dave explains why fitness alone isn’t protective, how early-life microbiome disruption and low-fiber modern diets stack long-term risk, and why earlier screening and gut-supportive habits like fiber, resistant starch, and circadian alignment matter more than ever. Source: https://www.businessinsider.com/why-so-many-young-people-getting-colon-cancer-answer-infancy-2025-12  • Kefir-Derived Bacteria, Immune Aging, and the Thymus A mouse study found that a kefir-derived bacterial strain, even when heat-inactivated, reduced age-related thymus shrinkage and lowered inflam

You’re about to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshaped what’s allowed in the food supply and why these decisions are driving chronic inflammation, immune dysfunction, and neurological breakdown at scale. This episode exposes how biotoxins, ultra processed ingredients, and systemic regulatory failures contribute to long COVID, POTS, mold illness, chronic fatigue, and dysautonomia and why so many people feel sick despite following official health guidance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Will Cole, a functional medicine expert who works extensively with autoimmune disease, mold illness, hormonal dysfunction, digestive disorders, and complex brain related symptoms. Dr. Cole brings years of clinical experience analyzing lab data and treating patients with biotoxin exposure, neuro immune dysregu

This solo masterclass on oxalates explains why many people who eat clean still struggle with joint pain, kidney stones, fatigue, brain fog, and chronic inflammation. You’ll learn how oxalates behave very differently from other plant compounds like lectins, phytates, and salicylates. Unlike those compounds, oxalates physically bind minerals and form microscopic crystals that can lodge in tissues, damage mitochondria, and accumulate over time. This episode will change how you think about superfoods, clean eating, and long term human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey walks you through the real science of oxalates using decades of self experimentation, functional medicine research, and hands on biohacking. As the founder of the biohacking movement, Dave has tested fasting, ketosis, carnivore strategies, supplements, nootropics, sleep optimization protocols, and metabolic interven

This video reveals the hidden mistake most people make when fasting that causes muscle loss instead of fat loss. You’ll learn how to flip the body’s fat-burning switch so your fast protects muscle, boosts energy, and actually melts fat. It’s positioned around one of the many solutions Dave did to lose 100 pounds.*** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. ***Thank you to our sponsors! -HeartMath | Go to https://www.heartmath.com/dave to save 15% off.-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.*Chapters*00:00 - I used to weigh 300 pounds00:48 - Fasting wrong makes you better at storing fat01:25 - When fasting burns muscle instead of fat02:44 - Muscle: the "organ of longevity"07:03 - Daily habits that sabotage fat burning08:29 - Steps to flip the switch faster10:13 - How to break a fast correctly (critical!)11:45 - The sweet spotResour

This episode covers: • Trump Drug Pricing Deals and Access to Longevity Medications New drug-pricing agreements announced under President Donald Trump aim to lower the cost of high-priced prescription drugs through negotiated rebates and pricing pressure on major pharmaceutical companies. Early reporting suggests these changes could affect cardiometabolic and longevity-relevant medications, including GLP-1 diabetes and obesity drugs. Dave explains why the real question is not headline savings, but whether lower prices actually reach patients at the pharmacy counter. He breaks down how affordability shapes real-world access, adherence, and long-term prevention strategies, and why policy decisions can matter more than new mechanisms when it comes to sustainable longevity care. Source: https://longevity.technology/news/trump-sets-new-drug-pricing-deals-with-big-pharma/  • 5:2 Intermittent Fasting Outperforms Daily Dieting on Metabolic Health A controlled study compare

The holidays are when drinking quietly ramps up for a lot of people. More parties, more stress, more excuses, and habits that feel temporary but often aren’t. This episode is for anyone reflecting on their relationship with alcohol, substances, or compulsive habits and questioning whether those patterns are actually supporting the life and health they want going forward. This episode features host Dave Asprey joined by Luke Storey, a motivational speaker, spiritual teacher, and host of the top-rated podcast The Life Stylist, which has surpassed 10 million downloads. Luke is widely regarded as a pioneer in health and wellness, known for articulating transformative principles around spirituality, addiction recovery, and mental, emotional, and physical health optimization. Together, Dave and Luke explore why getting sober and staying sober rarely comes down to willpower alone. They unpack how addiction often shows up as biology, trauma, nervous system dysregulation, a